Trifluoroacetic acid → HCID 23114806, compound

Participants

Reaction Steps

To a solution of N-[5-chloro-4-[(4-chlorophenylsulfonyl)(2,5-difluorophenyl)methyl]pyridin-2-yl]-N-(trifluoromethylsulfonyl)trifluoromethanesulfonamide (77 mg, 0.111 mmol) in a mixture of tetrahydrofuran (5 ml) and water (1 ml) was added lithium hydroxide monohydrate (5.0 mg, 0.111 mmol). The resulting mixture was stirred at room temperature for 5 hours. To the reaction mixture was added a saturated aqueous solution of ammonium chloride, followed by extraction with ethyl acetate. The organic layer was washed with brine, dried over anhydrous sodium sulfate, and filtered. The filtrate was concentrated under reduced pressure. The residue thus obtained was subjected to silica gel column chromatography. The fraction obtained from the hexane:ethyl acetate (=2:1) eluate containing 0.5% trifluoroacetic acid was concentrated under reduced pressure. To the residue thus obtained was added ether, and the solid thus precipitated was collected by filtration to give the title compound (39 mg, 0.069 mmol, 63%) as a white powder.

Provenance & Evidence