Hydrochloric Acid → HCID 23114891, compound

Participants

Reaction Steps

To an ethanol (5 ml) solution of t-butyl 4-[2-[[[5-chloro-4-[(4-chlorophenylsulfonyl)(2,5-difluorophenyl)methyl]pyridin-2-yl]amino]sulfonyl]ethyl]piperazine-1-carboxylate (72 mg, 0.102 mmol) was added concentrated hydrochloric acid (1 ml). The resulting mixture was stirred at room temperature for 2 days, followed by concentration under reduced pressure. To the residue thus obtained was added a saturated aqueous solution of sodium bicarbonate. The resulting mixture was extracted with methylene chloride. The organic layer was dried over anhydrous sodium sulfate, and filtered. The filtrate was concentrated under reduced pressure. The residue thus obtained was washed with ether to give the title compound (23 mg, 0.038 mmol, 37%) as a white powder.

Provenance & Evidence