Trifluoroacetic acid → HCID 59745530, compound

Participants

Reaction Steps

A solution was made of 1-tert-butyl 2-ethyl rel-(2S,3aS,7aR)-6-(3-methyl butanoyl)octahydro-1H-pyrrolo[2,3-c]pyridine-1,2-dicarboxylate obtained under step a) (0.335 mmol) in DCM (2.5 mL), to which TFA (2.5 mL) was added. The reaction was left to stir for 1 hour after which time it was checked by TLC (60% EtOAc in heptanes). If the reaction had not gone to completion after this time it was left stirring and checked after every additional ½. Generally this took 2 hours. When the reaction had gone to completion the TFA/DCM was removed in vacuo before being placed on a high vacuum line for 2 hours. The product was used in the next step with no further purification.

Provenance & Evidence