Tetrahydrofuran → HCID 59745553, compound

Participants

Reaction Steps

A solution of ethyl rel-(2S,3aS,7aR)-6-[2-(ethylamino)-2-oxoethyl]-1-[(4-methoxyphenyl)sulfonyl]octahydro-1H-pyrrolo[2,3-c]pyridine-2-carboxylate under step a) (62 mg, 0.13 mmol) was made in 1:1 THF:H2O (20 vols). Lithium hydroxide monohydrate (65.5 mg, 1.56 mmol) was added and the reaction stirred at room temperature for 18 hours. The THF was removed in vacuo, and the aqueous layer extracted with EtOAc (3×10 mL). The organic extracts were collected, dried over magnesium sulfate and filtered. The solvent was then removed in vacuo, before being placed on a high vacuum line for 2 hours. The product was used in the next step with no further purification.

Provenance & Evidence