Sodium Hydroxide → HCID 59745537, compound

Participants

Reaction Steps

To a solution of ethyl 6-acetyl-1-[(4-methoxyphenyl)sulfonyl]-4,5,6,7-tetrahydro-1H-pyrrolo[2,3-c]pyridine-2-carboxylate obtained in Example 2 under step c) (500 mg, 1.23 mmol) in ethanol (22.5 mL) at room temperature was added sodium hydroxide solution (590 mg, 14.76 mmol, 12 eq., in 22.5 mL H2O). The reaction mixture was stirred at rt for 48 hours and partitioned between 1 N HCl and EtOAc. The combined organic layers were dried over Na2SO4 and concentrated. Purification by preparative HPLC followed by lyophilisation gave the title compound (183 mg, 39%).

Provenance & Evidence