4-Toluenesulfonyl chloride → HCID 86623646, compound

Participants

Reaction Steps

2-(2-chlorophenyl)-2-hydroxyacetonitrile (16.8 g, 0.1 mol) and 4-toluene sulfonyl chloride (21 g, 0.11 mol) was dissolved in toluene (100 mL) in a suitable reaction flask. Aqueous 5% NaOH (100 g, 0.125 mol) was added dropwise at 0-5° C. and the reaction continued at 10-15° C. until the reaction was completed by TLC monitoring. The organic layer was separated and the aqueous layer was extracted with toluene (50 ml×2). The combined organic layer was washed with water. After removal of toluene under reduced pressure, the target product was obtained (29 g, yield 90.6%).

Provenance & Evidence