Hydrochloric Acid → HCID 86623646, compound

Participants

Reaction Steps

(s)-2-(2-chlorophenyl)-2-hydroxyacetonitrile (16.8 g, 0.1 mol) and 4-toluene sulfonyl chloride (21 g, 0.11 mol) was dissolved in butyl acetate (100 mL) in a suitable reaction flask. N,N-dimethyl aniline (10 mL) was added dropwise to the mixture at 0-5° C. and the reaction continued at 20-25° C. for 3 hours, and then refluxed till the reaction was completed by TLC monitoring. Cold down the reaction mixture, 5% HCl (50 mL) was added and stirred at room temperature. Butyl acetate layer was separated and washed with water (50 ml×2). After removal of the solvent under reduced pressure, the target product was obtained (31 g, yield 96.9%).

Provenance & Evidence