Isobutyraldehyde → HCID 86646581, compound

Participants

Reaction Steps

This compound was made in a manner analogous to that set forth in Step A of Example 3, using 2.0 grams (0.0062 mole) of [(6-chloro(3-pyridyl))methyl]{2-[(4-methoxyphenyl)methylthio]ethyl}-amine, 0.45 gram (0.0062 mole) of isobutyraldehyde, 2.0 gram (0.0093 mole) of sodium triacetoxyborohydride and 1.5 grams (0.0124 mole) of magnesium sulfate in 40 mL of 1,2-dichloroethane. The yield of the subject compound after one column chromatography purification on silica gel, eluting with a mixture of ethyl acetate and hexanes, was 2.05 grams. The NMR spectrum was consistent with the proposed structure.

Provenance & Evidence