Sodium Hydroxide → HCID 66918073, Verbindung

HRID 2080562Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2080562
[Cl:1][C:2]1[C:3]([CH:9]2[CH2:11][CH:10]2[C:12]([O:14]CC)=[O:13])=[N:4][CH:5]=[C:6]([Cl:8])[CH:7]=1.[OH-].[Na+]>C(O)C>[Cl:1][C:2]1[C:3]([CH:9]2[CH2:11][CH:10]2[C:12]([OH:14])=[O:13])=[N:4][CH:5]=[C:6]([Cl:8])[CH:7]=1

Komponenten

4

Edukt 2

HCID 14798Sodium HydroxideHCID 66918072HCID 66918072, Verbindung

Produkt 1

HCID 66918073HCID 66918073, VerbindungAusbeute 91,8 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel

Versuchsvorschrift

1.65 g of ethyl 2-(3,5-dichloropyridin-2-yl)cyclopropanecarboxylate (0.00634 mol) are dissolved in 20 ml of ethanol, 9.5 ml of sodium hydroxide 1M are added to the reaction mixture which is refluxed for 4 hours and left at room temperature overnight. After concentration in vacuo, 30 ml of water are added to the reaction mixture which is extracted twice with ethyl acetate (20 ml). The aqueous phase is acidified with HCl 1M. The precipate which forms is filtered, air-dried to yield to 1.35 g of 2-(3,5-dichloropyridin-2-yl)cyclopropanecarboxylic acid (87%).

Aufarbeitung

  1. temperatureis refluxed for 4 hours
  2. concentrationAfter concentration in vacuo, 30 ml of water
  3. additionare added to the reaction mixture which
  4. extractionis extracted twice with ethyl acetate (20 ml)
  5. filtrationThe precipate which forms is filtered
  6. customair-dried

Quellen und Nachweise

ORD-Eintrag
ord-c6ef5c40c0354a42b7ca6bba3d5c12a0
Quelldatensatz
uspto-grants-2011_04
Patentnummer
US07932396B2

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