Trifluoroacetic acid → HCID 67110747, compound

Participants

Reaction Steps

0.800 g of tert-butyl[2-(3,5-dichloropyridin-2-yl)cyclopropyl](2-iodobenzoyl)carbamate (0.00075 mol) are dissolved in 7 ml of dichloromethane. 0.70 ml of trifluoroacetic acid are added to the reaction mixture which is left stirring at room temperature overnight. The reaction mixture is quenched with 15 ml of an aqueous solution of saturated sodium bicarbonate. After separation, the aqueous phase is extracted with dichloromethane (10 ml). The combined organic phases are dried over magnesium sulfate, filtered, concentrated to dryness and purified on silica to yield to 245 mg of N-[2-(3,5-dichloropyridin-2-yl)cyclopropyl]-2-iodobenzamide (65%).

Provenance & Evidence