Chlorosulfonic acid → HCID 86619516, compound

HRID 2080649Notes

Reaction equation

HRID 2080649 reaction equation
[CH3:1][O:2][C:3]1[CH:8]=[C:7]([O:9][CH3:10])[CH:6]=[CH:5][C:4]=1[C:11]1[N:15]([C:16]2[CH:21]=[CH:20][CH:19]=[CH:18][C:17]=2[Cl:22])[N:14]=[CH:13][CH:12]=1.[Cl:23][S:24](O)(=[O:26])=[O:25]>>[Cl:23][S:24]([C:6]1[C:7]([O:9][CH3:10])=[CH:8][C:3]([O:2][CH3:1])=[C:4]([C:11]2[N:15]([C:16]3[CH:21]=[CH:20][CH:19]=[CH:18][C:17]=3[Cl:22])[N:14]=[CH:13][CH:12]=2)[CH:5]=1)(=[O:26])=[O:25]

Participants

3

Reactant 2

HCID 24638Chlorosulfonic acidHCID 66949344HCID 66949344, compound

Product 1

HCID 86619516HCID 86619516, compound

Procedure

8.1 18.0 g of 5-(2,4-dimethoxyphenyl)-1-(2-chlorophenyl)-1H-pyrazole (“B1”; obtainable analogously to Example 1) are added at −5° to 30 ml of chlorosulfonic acid, and the mixture is stirred at room temperature for a further 3 hours. The mixture is poured onto ice, the precipitated crystals are separated off and washed with water, giving 23.6 g of 5-(5-chlorosulfonyl-2,4-dimethoxyphenyl)-1-(2-chlorophenyl)-1H-pyrazole (“B2”).

Workup

  1. additionThe mixture is poured onto ice
  2. customthe precipitated crystals are separated off
  3. washwashed with water

Sources & evidence

ORD record
ord-c1812a69f10a4b989e9a306e5784fa3f
Source dataset
uspto-grants-2011_04
Patent number
US07932401B2

Reaction notes

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