HCID 67100599, compound → HCID 136382795, compound

HRID 2080652Notes

Reaction equation

HRID 2080652 reaction equation
[C:1]([C:4]1[CH:5]=[C:6]([CH2:10][CH2:11][C:12]2[C:13]([O:32]C)=[CH:14][C:15]([O:30]C)=[C:16]([C:18]3[N:22]([C:23]4[CH:28]=[CH:27][CH:26]=[CH:25][C:24]=4[Cl:29])[N:21]=[CH:20][CH:19]=3)[CH:17]=2)[CH:7]=[CH:8][CH:9]=1)([OH:3])=[O:2]>CCOCC>[C:1]([C:4]1[CH:5]=[C:6]([CH2:10][CH2:11][C:12]2[C:13]([OH:32])=[CH:14][C:15]([OH:30])=[C:16]([C:18]3[N:22]([C:23]4[CH:28]=[CH:27][CH:26]=[CH:25][C:24]=4[Cl:29])[N:21]=[CH:20][CH:19]=3)[CH:17]=2)[CH:7]=[CH:8][CH:9]=1)([OH:3])=[O:2]

Participants

3

Reactant 1

HCID 67100599HCID 67100599, compound

Product 1

HCID 136382795HCID 136382795, compound

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Procedure

Analogous reaction of “E2a” with 3-carboxystyrene gives the compound 5-[5-(3-carboxystyryl)-2,4-dimethoxyphenyl]1-(2-chlorophenyl)-1H-pyrazole and hydrogenation thereof gives 5-{5-[2-(3-carboxyphenyl)ethyl]2,4-dimethoxyphenyl}-1-(2-chlorophenyl)-1H-pyrazole. Ether cleavage gives 5-{5-[2-(3-carboxyphenyl)ethyl]2,4-dihydroxyphenyl}-1-(2-chlorophenyl)-1H-pyrazole.

Sources & evidence

ORD record
ord-3b42547081ca4dc1999f20883ac0c3a0
Source dataset
uspto-grants-2011_04
Patent number
US07932401B2

Reaction notes

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