Methanol → Methyl 2-fluoro-4-nitrobenzoate

HRID 2080662Notes

Reaction equation

HRID 2080662 reaction equation
S(=O)(=O)(O)O.[F:6][C:7]1[CH:15]=[C:14]([N+:16]([O-:18])=[O:17])[CH:13]=[CH:12][C:8]=1[C:9]([OH:11])=[O:10].[CH3:19]O>>[F:6][C:7]1[CH:15]=[C:14]([N+:16]([O-:18])=[O:17])[CH:13]=[CH:12][C:8]=1[C:9]([O:11][CH3:19])=[O:10]

Participants

4

Reactant 3

HCID 887MethanolHCID 1118Sulfuric AcidHCID 3026792-Fluoro-4-nitrobenzoic acid

Product 1

HCID 3013872Methyl 2-fluoro-4-nitrobenzoate

Procedure

5 ml of concentrated sulfuric acid was added to a methanol (1300 ml) solution of 140 g of 2-fluoro-4-nitrobenzoic acid, and heated under reflux for 48 hours. The solvent was evaporated away under reduced pressure, water was added to the residue, and the formed solid was taken out through filtration. This was dried under reduced pressure to obtain 141 mg of the entitled compound as a yellow solid.

Workup

  1. temperatureheated
  2. temperatureunder reflux for 48 hours
  3. customThe solvent was evaporated away under reduced pressure, water
  4. additionwas added to the residue
  5. filtrationthe formed solid was taken out through filtration
  6. customThis was dried under reduced pressure

Sources & evidence

ORD record
ord-58c7b7a77316482f8a3e6db1a407022d
Source dataset
uspto-grants-2011_04
Patent number
US07932394B2

Reaction notes

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