Nitric Acid → HCID 57433540, compound

HRID 2080665Notes

Reaction equation

HRID 2080665 reaction equation
[N+:1]([O-:4])(O)=[O:2].[F:5][C:6]1[CH:15]=[C:14]([NH:16][C:17]([C:19]2[CH:24]=[CH:23][CH:22]=[CH:21][N:20]=2)=[O:18])[CH:13]=[CH:12][C:7]=1[C:8]([O:10][CH3:11])=[O:9].C(=O)([O-])[O-].[Na+].[Na+]>O>[F:5][C:6]1[CH:15]=[C:14]([NH:16][C:17]([C:19]2[CH:24]=[CH:23][CH:22]=[CH:21][N:20]=2)=[O:18])[C:13]([N+:1]([O-:4])=[O:2])=[CH:12][C:7]=1[C:8]([O:10][CH3:11])=[O:9]

Participants

5

Reactant 3

HCID 944Nitric AcidHCID 10340Sodium CarbonateHCID 57433539Methyl 2-fluoro-4-[(pyridine-2-carbonyl)amino]benzoate

Product 1

HCID 57433540HCID 57433540, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

With cooling with ice, 110 ml of fuming nitric acid was gradually added to 27.7 g of methyl 2-fluoro-4-[(2-pyridinylcarbonyl)amino]benzoate, and stirred at room temperature for 1.5 hours. With cooling with ice, the reaction liquid was gradually added to a solution of sodium carbonate (138 g) in water (2000 ml), and the formed solid was taken out through filtration. This was dried under reduced pressure to obtain 27.5 g of the entitled compound as a yellow solid.

Workup

  1. temperatureWith cooling with ice
  2. customthe reaction liquid
  3. filtrationthe formed solid was taken out through filtration
  4. customThis was dried under reduced pressure

Sources & evidence

ORD record
ord-870e307c5bb8410aaae104a10e2bf771
Source dataset
uspto-grants-2011_04
Patent number
US07932394B2

Reaction notes

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