HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sulfuric Acid → 5-Fluoro-2-nitrobenzoic acid methyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sulfuric Acid | HCID 1118 | — |
| Reactant | Sodium Bicarbonate | HCID 516892 | — |
| Reactant | 5-Fluoro-2-nitrobenzoic acid | HCID 2737420 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 5-Fluoro-2-nitrobenzoic acid methyl ester | HCID 5152049 | — |
Reaction Steps
2 ml of concentrated sulfuric acid was added to a methanol (200 ml) solution of 10 g of 5-fluoro-2-nitrobenzoic acid, and heated under reflux for 22 hours. 200 ml of aqueous sodium hydrogencarbonate solution was added to it, and the formed solid was taken out through filtration. This was dried under reduced pressure to obtain 10.7 g of the entitled compound as a yellow solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07932394B2 |
| Source dataset | uspto-grants-2011_04 |
| ORD ID | ord-7e8e35b518134815b76626eae3210099 |
| Source note | uspto-grants-2011_04 |