HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2080668Generated: October 31, 2026
Dimethylformamide → Methyl 5-[4-(ethylsulfonyl)phenoxy]-2-nitrobenzoate
https://huagongshe.com/reaction/2080668
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Dimethylformamide | HCID 6228 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 5-Fluoro-2-nitrobenzoic acid methyl ester | HCID 5152049 | — |
| Reactant | 4-(Ethanesulfonyl)phenol | HCID 20236227 | — |
| Solvent | Water | HCID 962 | — |
| Product | Methyl 5-[4-(ethylsulfonyl)phenoxy]-2-nitrobenzoate | HCID 57433573 | 100.3% |
Reaction Steps
11 g of potassium carbonate was added to a dimethylformamide (150 ml) solution of 10.7 g of methyl 5-fluoro-2-nitrobenzoate and 11.1 g of 4-(ethylsulfonyl)phenol obtained from Reference Example 2, and stirred under heat at 80° C. for 90 minutes. The reaction liquid was restored to room temperature, then 300 ml of water was added to it, and the formed solid was taken out through filtration. This was dried under reduced pressure to obtain 19.7 g of the entitled compound as a creamy white solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US07932394B2 |
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| Source dataset | uspto-grants-2011_04 |
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| ORD ID | ord-01e8d790bb6d46edb016dc931f569a2d |
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| Source note | uspto-grants-2011_04 |
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