Ammonium Chloride → HCID 67110386, compound

Participants

Reaction Steps

With cooling with ice, 14 μl of a tetrahydrofuran solution of 3.0 M methylmagnesium bromide was added to a tetrahydrofuran (500 μl) solution of 8.7 mg of the compound obtained from Example 138, and stirred at room temperature for 30 minutes. then, 14 μl of a tetrahydrofuran solution of 3.0 M methylmagnesium bromide was added to it, and stirred at room temperature for 5 minutes. With cooling with ice, aqueous saturated ammonium chloride solution was added to it, extracted with chloroform, and the organic layer was washed with saturated saline water. After dried, the solvent was evaporated away under reduced pressure, and the residue was purified through partitioning thin-layer chromatography (Kieselgel™ 60F254, Art 5744 (by Merck), chloroform/methanol=20/1) to obtain 4.0 mg of the entitled compound.

Provenance & Evidence