Chloroform → HCID 57433640, compound

Participants

Reaction Steps

With cooling with ice, 0.33 ml of triethylamine and 210 mg of picolinic acid chloride were added to a chloroform (2 ml) solution of 144 mg of 1-(2-amino-5-{[6-(5-methyl-1,2,4-oxadiazol-3-yl)pyridin-3-yl]oxy}benzyl)pyrrolidin-2-one, and stirred at room temperature for 1 hour. Water was added to it, extracted with chloroform, the organic layer was dried, the solvent was removed, and the residue was purified through silica gel column chromatography (developing solvent: hexane/ethyl acetate=9/1 to 2/8) to obtain 117 mg of N-{4-{[6-(5-methyl-1,2,4-oxadiazol-3-yl)pyridin-3-yl]oxy}-2-[(2-oxopyrrolidin-1-yl)methyl]phenyl}pyridine-2-carboxamide as a pale yellow solid.

Provenance & Evidence