Trifluoroacetic acid → HCID 67110334, compound

Participants

Reaction Conditions

Reaction Steps

126 mg of potassium nitrate was added to a trifluoroacetic acid (3 ml) solution of 117 mg of N-{4-{[6-(5-methyl-1,2,4-oxadiazol-3-yl)pyridin-3-yl]oxy}-2-[(2-oxopyrrolidin-1-yl)methyl]phenyl}pyridine-2-carboxamide, and stirred under heat at 80° C. for 7 hours. Trifluoroacetic acid was evaporated away under reduced pressure, then chloroform was added to the residue, and washed with aqueous saturated sodium hydrogencarbonate solution. The organic layer was dried, and the solvent was evaporated away under reduced pressure to obtain 122 mg of N-{4-{[6-(5-methyl-1,2,4-oxadiazol-3-yl)pyridin-3-yl]oxy}-2-nitro-6-[(2-oxopyrrolidin-1-yl)methyl]phenyl}pyridine-2-carboxamide as a brown oil.

Provenance & Evidence