Imidazole → (S)-3-((tert-Butyldimethylsilyl)oxy)pyrrolidin-2-one

Participants

Reaction Steps

In an ice bath, 570 mg of imidazole and 947 mg of t-butyldimethylsilyl chloride were added to a dimethylformamide (5 ml) solution of 503 mg of (3S)-3-hydroxypyrrolidin-2-one, and stirred at room temperature for 1 hour. Water was added to the reaction liquid, extracted with ethyl acetate, the organic layer was washed with water and saturated saline water, and dried. The solvent was evaporated away under reduced pressure to obtain 452 mg of the entitled compound as a pale yellow oil.

Provenance & Evidence