Potassium Carbonate → Ethyl 5-fluoropyridine-2-carboxylate

Participants

Reaction Conditions

Reaction Steps

1.57 g of potassium carbonate, 0.34 g of 1,3-bis(diphenylphosphino)propane and 0.17 g of palladium acetate were added to a solution of 1 g of 2-chloro-5-fluoropyridine in 8 ml of dimethylformamide and 8 ml of ethanol, and stirred in a carbon monoxide atmosphere under heat at 90° C. for 2 hours. The reaction liquid was filtered, the filtrate was extracted with chloroform, and the organic layer was washed with saturated saline water. After dried, the solvent was evaporated away under reduced pressure, and the residue was purified through silica gel column chromatography (developing solvent: hexane/ethyl acetate) to obtain 0.97 g of the entitled compound as a white crystal.

Provenance & Evidence