反应详情

温度

0 °C

Lithium aluminum hydride (138 mg) was suspended in THF (7.0 ml) and then the whole was cooled to 0° C. After that, a THF solution (7.0 ml) containing the compound (361 mg) obtained in Example 3-3 was dropped in the suspension, followed by stirring at 0° C. for 1 hour. After completion of the reaction, sodium sulfate decahydrate was added to the solution until bubbling was stopped, and a 1 mol/l sodium hydroxide aqueous solution was then added to the mixture until a white precipitate was generated. The solid component was separated through filtration and the solvent was then distilled off from the filtrate under reduced pressure. The residue was dried under vacuum, thereby obtaining the subject compound (302 mg) as a pale-yellow oily substance.

1. additionwas dropped in the suspension
2. additionwas added to the solution
3. customuntil bubbling
4. additiona 1 mol/l sodium hydroxide aqueous solution was then added to the mixture until a white precipitate
5. customThe solid component was separated through filtration
6. distillationthe solvent was then distilled off from the filtrate under reduced pressure
7. customThe residue was dried under vacuum