HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2080732Generated: November 1, 2026
Thionyl Chloride → 2-(chloromethyl)-1-methyl-1H-imidazole hydrochloride
https://huagongshe.com/reaction/2080732
Participants
| Role | Name | HCID | Charge |
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| Reactant | Thionyl Chloride | HCID 24386 | — |
| Reactant | (1-methyl-1H-imidazol-2-yl)methanol | HCID 573612 | — |
| Product | 2-(chloromethyl)-1-methyl-1H-imidazole hydrochloride | HCID 2795406 | — |
Reaction Steps
The compound (56.1 g) obtained in Example 10-1 was gradually added to thionyl chloride (119 ml) under ice-cooling. After completion of dropping, the whole was refluxed at 65° C. for 15 minutes. Excess thionyl chloride was distilled off under reduced pressure and the solution was further subjected to azeotropic distillation with toluene, thereby obtaining a hydrochloride (82.4 g) of the subject compound as a yellow solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US07932281B2 |
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| Source dataset | uspto-grants-2011_04 |
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| ORD ID | ord-1db0528c9b4d418e82eff48a3d66eeec |
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| Source note | uspto-grants-2011_04 |
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