Acetic Acid → HCID 67103508, compound

Participants

Reaction Steps

The compound (219 mg) obtained in Example 13-2 was dissolved in methanol (4.2 ml). The solution was added with acetic acid (200 μl), sodium cyanoborohydride (170.9 mg), and gradually added with propionaldehyde (180 μl) and the whole was stirred at room temperature for 2 hours. After completion of the reaction, the solvent was distilled off under reduced pressure. Then, the residue was dissolved in chloroform and washed with a 1 mol/l sodium hydroxide aqueous solution, followed by extraction with chloroform. The organic layer was washed with a saturated saline solution and then dried with anhydrous sodium sulfate. After filtration, the solvent was distilled off under reduced pressure, thereby obtaining the subject compound (305 mg) as a brown oily substance.

Provenance & Evidence