反应详情

The compound (83.0 mg) obtained in Example 18-4 was dissolved in methanol (1.0 ml) and added with a 4 mol/l hydrogen chloride/dioxane solution (1.0 ml) and the whole was stirred at room temperature for 6 hours. After completion of the reaction, the solvent was distilled off under reduced pressure. The residue was dissolved in methanol to generate a free compound therefrom through an anion-exchange resin (Amberlite IRA-410). The resin was separated by filtration and the filtrate subjected to distillation of the solvent under reduced pressure. The residue was purified through silica gel column chromatography (chloroform/ethyl acetate), thereby obtaining the subject compound (44.0 mg) as a brown solid.

1. customAfter completion of the reaction
2. distillationthe solvent was distilled off under reduced pressure
3. dissolutionThe residue was dissolved in methanol
4. customThe resin was separated by filtration
5. distillationthe filtrate subjected to distillation of the solvent under reduced pressure
6. customThe residue was purified through silica gel column chromatography (chloroform/ethyl acetate)