反应详情

An ethanol solution (20 ml) containing the compound (40.2 mg) obtained in Example 19-2 was added with an ethanol suspension of Raney nickel and a 1 mol/l sodium hydroxide aqueous solution (2.0 ml), and the whole was stirred at room temperature for 14 hours under a hydrogen atmosphere. The catalyst was removed by filtration through Celite. The residue obtained by distilling the solvent off under reduced pressure was dissolved in chloroform, washed with water and a saturated saline solution, and dried with anhydrous sodium sulfate. The solvent was distilled off, thereby obtaining the subject compound (40.1 mg) as a yellow oily substance.

1. customThe catalyst was removed by filtration through Celite
2. customThe residue obtained
3. distillationby distilling the solvent off under reduced pressure
4. dissolutionwas dissolved in chloroform
5. washwashed with water
6. dry with materiala saturated saline solution, and dried with anhydrous sodium sulfate
7. distillationThe solvent was distilled off