反应详情

The compound (260 mg) obtained in Example 23-4 was dissolved in methanol (5.0 ml) and added with distilled water (1.0 ml) and acrylonitrile (87.4 μl) and the whole was stirred overnight at room temperature. After completion of the reaction, the solvent was distilled off and the resultant was subjected to extraction with chloroform and washed with a saturated saline solution. The organic layer was dried with anhydrous sodium sulfate. The solvent was distilled off, thereby obtaining the subject compound (332 mg) as a colorless oily substance.

1. customAfter completion of the reaction
2. distillationthe solvent was distilled off
3. extractionthe resultant was subjected to extraction with chloroform
4. washwashed with a saturated saline solution
5. dry with materialThe organic layer was dried with anhydrous sodium sulfate
6. distillationThe solvent was distilled off