HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2080806Generated: November 2, 2026
Methanol → {3-[6-(4-Aminomethyl-phenyl)-pyridin-2-yl]-propyl}-dipropyl-amine
https://huagongshe.com/reaction/2080806
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Methanol | HCID 887 | — |
| Reactant | Hydrazine hydrate (1:1) | HCID 24654 | — |
| Reactant | 2-{4-[6-(3-Dipropylamino-propyl)-pyridin-2-yl]-benzyl}-isoindol-1,3-dione | HCID 23155452 | — |
| Solvent | Chloroform | HCID 6212 | — |
| Product | {3-[6-(4-Aminomethyl-phenyl)-pyridin-2-yl]-propyl}-dipropyl-amine | HCID 23155536 | 105.3% |
Reaction Steps
A methanol solution (2.0 ml) containing the compound (40.0 mg) obtained in Example 36-4 was added with hydrazine monohydrate (44 mg) and the whole was stirred at 60° C. for 1.5 hours, followed by distillating off the solvent. The residue was dissolved in chloroform and filtrated through Celite, the solvent was distilled off, thereby obtaining the subject compound (30.1 mg) as an amber liquid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US07932281B2 |
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| Source dataset | uspto-grants-2011_04 |
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| ORD ID | ord-e296b3619ace4450931041a4571e2bfa |
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| Source note | uspto-grants-2011_04 |
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