反应详情

An anhydrous methanol solution (0.50 ml) containing the compound (30.1 mg) obtained in Example 36-5 and 2-imidazole carboxaldehyde (10.1 mg) was added with trimethyl orthoformate (0.029 ml), and the whole was stirred at room temperature for 14 hours. Sodium borohydride (17.0 mg) was added thereto and the whole was stirred for 30 minutes. The solvent was distilled off. The residue was dissolved in chloroform, washed with a saturated aqueous sodium hydrogen carbonate solution, and dried with anhydrous sodium sulfate, and the solvent was distilled off, thereby obtaining the subject compound (30.4 mg).

1. stirringthe whole was stirred for 30 minutes
2. distillationThe solvent was distilled off
3. dissolutionThe residue was dissolved in chloroform
4. washwashed with a saturated aqueous sodium hydrogen carbonate solution
5. dry with materialdried with anhydrous sodium sulfate
6. distillationthe solvent was distilled off