Lawesson's reagent → HCID 23155557, compound

HRID 2080811Notes

Reaction equation

HRID 2080811 reaction equation
[C:1]([C:3]1[CH:8]=[CH:7][C:6]([NH:9][C:10](=O)[C:11]2[CH:16]=[CH:15][C:14]([CH3:17])=[CH:13][CH:12]=2)=[CH:5][CH:4]=1)#[N:2].COC1C=CC(P2(SP(C3C=CC(OC)=CC=3)(=S)S2)=[S:28])=CC=1>C1(C)C=CC=CC=1>[C:1]([C:3]1[CH:8]=[CH:7][C:6]([NH:9][C:10](=[S:28])[C:11]2[CH:16]=[CH:15][C:14]([CH3:17])=[CH:13][CH:12]=2)=[CH:5][CH:4]=1)#[N:2]

Participants

4

Reactant 2

HCID 87949Lawesson's reagentHCID 4994359HCID 4994359, compound

Product 1

HCID 23155557HCID 23155557, compoundYield 135.4%

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

The compound (1.26 g) obtained in Example 43-1 was dissolved in toluene (20 ml) and added with a Lawesson's reagent (1.29 g) and the whole was refluxed under heating for 2 hours. The reaction solution was cooled to room temperature and the precipitated solid was filtrated out. The resultant solid was subjected to recrystallization (methanol), thereby obtaining the subject compound (1.09 g) as a yellow solid.

Workup

  1. temperaturethe whole was refluxed
  2. temperatureunder heating for 2 hours
  3. filtrationthe precipitated solid was filtrated out
  4. customThe resultant solid was subjected to recrystallization (methanol)

Sources & evidence

ORD record
ord-41b2592ce2f4410ebb3534656fb7bbfb
Source dataset
uspto-grants-2011_04
Patent number
US07932281B2

Reaction notes

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