反应详情

The compound (242 mg) obtained in Example 45-3 was dissolved in DMF (5.0 ml). The solution was added with 60% sodium hydride (29.1 mg) and then 2-iodopropane (79.6 μl) in an ice bath. The whole was stirred overnight at room temperature. After completion of the reaction, the solvent was distilled off. The resultant was dissolved in chloroform and added with distilled water and the whole was stirred for a while. The solution was subjected to extraction with chloroform and washed with a saturated saline solution. The organic layer was dried with anhydrous sodium sulfate. The solvent was distilled off, and the residue was purified through silica gel column chromatography (hexane/ethyl acetate), thereby obtaining the subject compound (44.1 mg) as a pale-yellow oily substance.

1. customAfter completion of the reaction
2. distillationthe solvent was distilled off
3. dissolutionThe resultant was dissolved in chloroform
4. additionadded with distilled water
5. stirringthe whole was stirred for a while
6. extractionThe solution was subjected to extraction with chloroform
7. washwashed with a saturated saline solution
8. dry with materialThe organic layer was dried with anhydrous sodium sulfate
9. distillationThe solvent was distilled off
10. customthe residue was purified through silica gel column chromatography (hexane/ethyl acetate)