反应详情

The compound (44.1 mg) obtained in Example 47-1 was dissolved in anhydrous methanol (1.0 ml) and added with a 4 mol/l hydrogen chloride/dioxane solution (1.0 ml) and the whole was stirred at room temperature for 3 hours. After completion of the reaction, the solvent was distilled off. The resultant was added with a 1 mol/l sodium hydroxide aqueous solution and the whole was subjected to extraction with chloroform and washed with a saturated saline solution. The organic layer was dried with anhydrous sodium sulfate. The solvent was distilled off, thereby obtaining the subject compound (26.0 mg) as a white crystal.

1. customAfter completion of the reaction
2. distillationthe solvent was distilled off
3. additionThe resultant was added with a 1 mol/l sodium hydroxide aqueous solution
4. extractionthe whole was subjected to extraction with chloroform
5. washwashed with a saturated saline solution
6. dry with materialThe organic layer was dried with anhydrous sodium sulfate
7. distillationThe solvent was distilled off