HCID 67103493, compound → HCID 23155478, compound

HRID 2080831Notes

Reaction equation

HRID 2080831 reaction equation
C(OC(=O)[NH:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][C:16]1[N:20]([CH2:21][CH2:22][CH3:23])[C:19]2[CH:24]=[C:25]([C:28]#[N:29])[CH:26]=[CH:27][C:18]=2[N:17]=1)C1C=CC=CC=1>C(O)C.[C].[Pd]>[NH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][C:16]1[N:20]([CH2:21][CH2:22][CH3:23])[C:19]2[CH:24]=[C:25]([C:28]#[N:29])[CH:26]=[CH:27][C:18]=2[N:17]=1

Participants

4

Reactant 1

HCID 67103493HCID 67103493, compound

Product 1

HCID 23155478HCID 23155478, compoundYield 35.8%

Reagents, catalysts & solvents 2

HCID 178418390HCID 178418390, compoundCatalystHCID 702EthanolSolvent

Procedure

The compound (107 mg) obtained in Example 48-3 was dissolved in ethanol (10 ml) and added with palladium carbon (20 mg) and the whole was stirred for 20 hours under a hydrogen atmosphere. After filtration through Celite, the solvent was distilled off. The residue was purified through silica gel column chromatography (chloroform/methanol), thereby obtaining the subject compound (25.6 mg) as a white solid.

Workup

  1. filtrationAfter filtration through Celite
  2. distillationthe solvent was distilled off
  3. customThe residue was purified through silica gel column chromatography (chloroform/methanol)

Sources & evidence

ORD record
ord-bbf14fe4f90b4a1bb20bb744d44f86a9
Source dataset
uspto-grants-2011_04
Patent number
US07932281B2

Reaction notes

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