Acetic Acid → HCID 23155476, compound

Participants

Reaction Steps

The compound (26.4 mg) obtained in Example 48-4 was dissolved in methanol (2.0 ml) and added with sodium cyanoborohydride (15.8 mg). After the solution was adjusted to pH 4 with acetic acid, propionaldehyde (0.020 ml) was added thereto and the whole was stirred at room temperature for 20 hours. After the solvent was distilled off, the resultant was neutralized with a saturated aqueous sodium hydrogen carbonate solution and the whole was subjected to extraction with chloroform. The organic layer was washed with a saturated aqueous sodium hydrogen carbonate solution and dried with anhydrous sodium sulfate. The solvent was distilled off, thereby obtaining the subject compound (29.4 mg) as a colorless oily substance.

Provenance & Evidence