Ethanol → HCID 58345798, compound

HRID 2080842Notes

Reaction equation

HRID 2080842 reaction equation
[CH2:1]([N:4]([CH2:37][CH2:38][CH3:39])[CH2:5][CH2:6][CH2:7][CH2:8][N:9]([CH2:15][C:16]1[CH:21]=[CH:20][C:19]([CH2:22][N:23]([CH2:31][C:32]2[NH:33][CH:34]=[CH:35][N:36]=2)[CH2:24][C:25]2[N:26]([CH3:30])[CH:27]=[CH:28][N:29]=2)=[CH:18][CH:17]=1)[CH2:10][CH2:11][C:12]([OH:14])=[O:13])[CH2:2][CH3:3].[CH2:40](O)[CH3:41]>>[CH2:40]([O:13][C:12](=[O:14])[CH2:11][CH2:10][N:9]([CH2:8][CH2:7][CH2:6][CH2:5][N:4]([CH2:1][CH2:2][CH3:3])[CH2:37][CH2:38][CH3:39])[CH2:15][C:16]1[CH:21]=[CH:20][C:19]([CH2:22][N:23]([CH2:31][C:32]2[NH:33][CH:34]=[CH:35][N:36]=2)[CH2:24][C:25]2[N:26]([CH3:30])[CH:27]=[CH:28][N:29]=2)=[CH:18][CH:17]=1)[CH3:41]

Participants

3

Reactant 2

HCID 702EthanolHCID 11591930HCID 11591930, compound

Product 1

HCID 58345798HCID 58345798, compound

Procedure

The compound (135.4 mg) obtained in Example 51-1 was suspended in ethanol (13.5 ml) and the whole was refluxed under heating for 16 hours. After completion of the reaction, the solvent was distilled off. The resultant was added with saturated sodium hydrogen carbonate aqueous solution and the whole was subjected to extraction with chloroform. The resultant was dried with magnesium sulfate and the solvent was distilled off, thereby obtaining the subject compound (127.0 mg) as a colorless oily substance.

Workup

  1. temperaturethe whole was refluxed
  2. temperatureunder heating for 16 hours
  3. customAfter completion of the reaction
  4. distillationthe solvent was distilled off
  5. additionThe resultant was added with saturated sodium hydrogen carbonate aqueous solution
  6. extractionthe whole was subjected to extraction with chloroform
  7. dry with materialThe resultant was dried with magnesium sulfate
  8. distillationthe solvent was distilled off

Sources & evidence

ORD record
ord-059d5ad94a5f48d9a75cc726fe23fa63
Source dataset
uspto-grants-2011_04
Patent number
US07932281B2

Reaction notes

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