1-Hydroxybenzotriazole → HCID 23155398, compound

Participants

Reaction Steps

Commercially available 3,4-diaminobenzonitrile (0.461 g) was dissolved in DMF (18.4 ml) and added with WSCI hydrochloride (0.996 g), HOBt (0.702 g), and the compound (0.844 g) obtained in Example 60-1 and the whole was stirred at room temperature for 3 days. The reaction solution was concentrated under reduced pressure. The residue was added with water and subjected to separation/extraction with chloroform. The organic layer was washed with a saturated saline solution and then dried with anhydrous sodium sulfate, followed by concentration under reduced pressure. The residue was purified through silica gel column chromatography (chloroform/methanol), thereby obtaining the subject compound (1.04 g) as a yellow oily substance.

Provenance & Evidence