反应详情

The compound (21.265 g) obtained in Example 72-1 was dissolved in ethanol (100 ml) and added with a 4 mol/l hydrogen chloride/dioxane solution (140 ml) and the whole was stirred at room temperature for 1 hour. Subsequently, the solution was stirred at 40° C. for 1 hour. After completion of the reaction, the solvent was distilled off. The resultant was added with a 1 mol/l sodium hydroxide aqueous solution to make the pH thereof to 12. The solution was subjected to extraction with chloroform and dried with magnesium sulfate. The solvent was distilled off, thereby obtaining the subject compound (16.46 g) as a colorless oily substance.

1. stirringSubsequently, the solution was stirred at 40° C. for 1 hour
2. customAfter completion of the reaction
3. distillationthe solvent was distilled off
4. additionThe resultant was added with a 1 mol/l sodium hydroxide aqueous solution
5. extractionThe solution was subjected to extraction with chloroform
6. dry with materialdried with magnesium sulfate
7. distillationThe solvent was distilled off