反应详情

温度

80 °C

The compound (190.7 mg) obtained in Example 65-1 was dissolved in 2-methoxyethanol (4.0 ml) and the whole was stirred at 80° C. for 21 hours. After completion of the reaction, the solvent was distilled off. The resultant was added with a saturated aqueous sodium hydrogen carbonate solution and the whole was subjected to extraction with chloroform and dried with magnesium sulfate. The solvent was distilled off. The residue was purified through silica gel column chromatography (chloroform/ethyl acetate) and treated with hydrochloric acid, thereby obtaining a hydrochloride (37.9 mg) of the subject compound as a white solid.

1. customAfter completion of the reaction
2. distillationthe solvent was distilled off
3. additionThe resultant was added with a saturated aqueous sodium hydrogen carbonate solution
4. extractionthe whole was subjected to extraction with chloroform
5. dry with materialdried with magnesium sulfate
6. distillationThe solvent was distilled off
7. customThe residue was purified through silica gel column chromatography (chloroform/ethyl acetate)
8. additiontreated with hydrochloric acid