Formic Acid → HCID 23155527, compound

Participants

Reaction Steps

The compound (310 mg) obtained in Example 88-1 was dissolved in ethanol (4.5 ml) and added with a 36% formaldehyde aqueous solution (150 μl) and formic acid (175 μl) and the whole was refluxed for 2 hours. After completion of the reaction, the solvent was distilled off under reduced pressure. The residue was dissolved in chloroform and washed with a 1 mol/l sodium hydroxide aqueous solution, followed by extraction with chloroform. The organic layer was washed with a saturated saline solution and dried with anhydrous sodium sulfate. After filtration, the solvent was distilled off under reduced pressure. The residue was purified through silica gel column chromatography (hexane/ethyl acetate), thereby obtaining the subject compound (234 mg) as a colorless oily substance.

Provenance & Evidence