Hydrochloride methanol → HCID 178457211, compound

Participants

Reaction Steps

The compound (35.6 mg) obtained in Example 91-4 was dissolved in methanol (0.80 ml) and added with a 10% hydrogen chloride/methanol solution (0.80 ml) and the whole was stirred overnight at room temperature. After completion of the reaction, the solvent was distilled off under reduced pressure. The residue was added with ethyl acetate and water, and the aqueous layer was washed with ethylacetate. The aqueous layer was concentrated and evaporated to dryness under reduced pressure, thereby obtaining a hydrochloride (23.9 mg) of the subject compound as a white solid.

Provenance & Evidence