Acetic Acid → HCID 59642133, compound

HRID 2080929Notes

Reaction equation

HRID 2080929 reaction equation
[N+:1]([C:4]1[CH:5]=[C:6]([CH:11]=[C:12]([S:14]([F:19])([F:18])([F:17])([F:16])[F:15])[CH:13]=1)[C:7]([O:9][CH3:10])=[O:8])([O-])=O.CC(O)=O.[H][H]>CO.[Pd]>[NH2:1][C:4]1[CH:5]=[C:6]([CH:11]=[C:12]([S:14]([F:19])([F:15])([F:16])([F:17])[F:18])[CH:13]=1)[C:7]([O:9][CH3:10])=[O:8]

Participants

6

Reactant 3

HCID 176Acetic AcidHCID 59642156HCID 59642156, compoundHCID 178418361HCID 178418361, compound2×

Product 1

HCID 59642133HCID 59642133, compoundYield 92.3%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

3.0 g of methyl 3-nitro-5-pentafluorosulfanylbenzoate were dissolved in 50 ml of MeOH and 5 ml of HOAc and 200 mg of Pd/C (10%) were added. The mixture was hydrogenated under a standard pressure of hydrogen atmosphere for 20 h, then hydrogenation was effected under 6 bar of hydrogen for a further 2 days. The catalyst was filtered off and the solvent removed under reduced pressure to obtain 2.5 g of an amorphous solid.

Workup

  1. filtrationThe catalyst was filtered off
  2. customthe solvent removed under reduced pressure

Sources & evidence

ORD record
ord-a970f133a7e94a34b4b58481ae0d6c73
Source dataset
uspto-grants-2011_04
Patent number
US07932416B2

Reaction notes

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