Nitric Acid → HCID 59642132, compound

Participants

Reaction Conditions

Reaction Steps

20.00 g of N-(3-pentafluorosulfanylphenyl)acetamide (preparation as in Tetrahedron 56, (2000) 3399) were dissolved in portions at from −35° C. to −40° C. in 100 ml of 90% HNO3. The mixture was stirred at −40° C. for 15 minutes, then poured onto 1 kg of ice and stirred at RT for 1 h. The product was then filtered, washed with water and dried under reduced pressure. Chromatography on silica gel using DIP afforded 3.61 g of N-(4-nitro-3-pentafluorosulfanylphenyl)acetamide as well as 17.00 g of N-(2-nitro-5-pentafluorosulfanylphenyl)acetamide.

Provenance & Evidence