Diethyl Ether → HCID 178425829, compound

Participants

Reaction Steps

To a solution of methyl 2-(4-(N-cyclopropyl-2-fluoro-4-methylbenzamido)cyclohexyl)acetate (0.075 g, 0.22 mmol) in THF (2 mL) was added methylmagnesium bromide, (3.0 M solution in diethyl ether, 0.43 ml, 1.3 mmol) at room temperature. After being stirred for 2 hours at room temperature, the reaction mixture was quenched with saturated NH4Cl (10 ml) and then extracted with EtOAc three times. The organic phase was dried over Na2SO4 and then concentrated in vacuo. The crude product was purified through silica gel chromatography eluting with 5% MeOH—CH2Cl2 and then 50% EtOAc-hexane. The desired product was obtained as a white solid (0.038 g). MS: 348 (M+1), C21H30FNO2.

Provenance & Evidence