HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2081067Generated: November 1, 2026
Hydrazine → 3-Hydroxy-4-methylbenzohydrazide
https://huagongshe.com/reaction/2081067
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Hydrazine | HCID 9321 | — |
| Reactant | 3-HYDROXY-4-METHYLBENZOIC ACID ETHYL ESTER | HCID 15745489 | — |
| Product | 3-Hydroxy-4-methylbenzohydrazide | HCID 16780936 | — |
Reaction Steps
A suspension of ethyl 3-hydroxy-4-methylbenzoate (14.42 g, 80 mmol) (from Example 2 supra) in anhydrous hydrazine (30 mL, 956 mmol) (Aldrich) was heated at reflux (150° C. bath temperature) for 2.0 hours. After cooling to room temperature, mixture was concentrated under reduced pressure (high vacuum) to give crude 3-hydroxy-4-methyl-benzoic acid hydrazide as an off-white solid. (Yield 13.26 g, 100%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US07932390B2 |
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| Source dataset | uspto-grants-2011_04 |
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| ORD ID | ord-b248f8cb9e5145f3b20e5416e2e22c05 |
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| Source note | uspto-grants-2011_04 |
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