p-Toluenesulfonic acid monohydrate → HCID 24810096, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of 4-amino-3-[2-methyl-5-(5-methyl-[1,3,4]oxadiazol-2-yl)-phenoxymethyl]-thieno[3,2-c]pyridine-7-carboxylic acid (2-hydroxy-ethyl)-amide (0.045 g, 0.10 mmol) (from Example 14 supra) in methanol (6 mL) was treated with toluene-4-sulfonic acid hydrate (19.5 mg, 0.10 mmol) (Aldrich) and heated at 40° C. for 30 minutes. The solution was concentrated. The residue washed with diethyl ether, dissolved ino water and lyophilized to give 4-amino-3-[2-methyl-5-(5-methyl-[1,3,4]oxadiazol-2-yl)-phenoxymethyl]-thieno[3,2-c]pyridine-7-carboxylic acid (2-hydroxy-ethyl)-amide toluene-4-sulfonic acid salt. (Yield 60.8 mg, 97%).

Provenance & Evidence