HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2081118Generated: November 2, 2026
Diisopropylethylamine → HCID 57463495, compound
https://huagongshe.com/reaction/2081118
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | Methanaminium, N-((dimethylamino)(3H-1,2,3-triazolo(4,5-b)pyridin-3-yloxy)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1) | HCID 9886157 | — |
| Reactant | HCID 59554296 | HCID 59554296 | — |
| Reactant | HCID 86611243 | HCID 86611243 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 57463495 | HCID 57463495 | — |
Reaction Steps
To a flask charged with ethyl-(1R,2S)-1-amino-2-vinylcyclopropyl carboxylate (1, 1.0 g, 5.2 mmol), 2-(tert-butoxycarbonyl)-6-(3-chlorophenoxy)-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid (2.31 g, 1.1 equiv), and O-(7-Azabenzotriazol-1-yl)-N,N,N′,N′-tetramethyluronium hexafluorophosphate (HATU) (2.7 g, 1.1 equiv) were added 30 mL DMF to make a solution. It was cooled to 0° C. in an ice-water bath, followed by slow addition of a solution of N,N-Diisopropylethylamine (DIEA) (4.4 mL, 4 equiv) in DMF (15 mL) while stirring. The reaction was allowed to warm up to rt and stirred overnight
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US07932277B2 |
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| Source dataset | uspto-grants-2011_04 |
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| ORD ID | ord-8e92b6ae21dd4c5c8acc1c18aaf98693 |
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| Source note | uspto-grants-2011_04 |
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