Sodium Hydroxide → HCID 67088600, compound

Participants

Reaction Steps

(1R,2S,5S)-methyl 3-((S)-3,3-dimethyl-2-(3-(trifluoromethyl)phenylamino)butanoyl)-6,6-dimethyl-3-aza-bicyclo[3.1.0]hexane-2-carboxylate (0.047 g, 0.11 mmol) in THF (1 mL) was added 0.4 N NaOH solution (0.69 mL, 0.28 mmol) and the reaction was stirred at rt for 3 hrs. THF was removed and acidified with saturated KHSO4 until PH=3˜4. The mixture was extracted with Ether (15 mL), washed with brine and dried over sodium sulfate. After removal of solvent, it gave the (1R,2S,5S)-3-((S)-3,3-dimethyl-2-(3-trifluoromethyl)phenylamino)butanoyl)-6,6-dimethyl-3-azabicyclo[3.1.0]hexane-2-carboxylic acid (0.043 g, 95%) as white solid. MS: Calcd.: 412; Found: [M−H]+ 411.

Provenance & Evidence