Potassium Carbonate → HCID 57988400, compound

Participants

Reaction Steps

(S)-2-amino-3,3-dimethylbutanoic acid (0.50 g, 3.81 mmol), K2CO3 (1.580 g, 11.44 mmol), copper(I) iodide (0.073 g, 0.38 mmol) and 1-bromo-3-fluoro-5-(trifluoromethyl)benzene (2.32 g, 9.53 mmol) in DMA (4 mL) was heated at 95° C. for 32 hrs. H2O (15 mL) and ethyl ether (20 ml) was added. The aqueous phase was isolated and acidified with saturated KHSO4 solution, extracted with ether, dried over sodium sulfate. After removal of solvent, it gave (S)-2-(3-fluoro-5-(trifluoromethyl)phenylamino)-3,3-dimethylbutanoic acid (0.78 g, 70%) as white solid. LCMS (APCI−): 292.2. 1H NMR (400 MHz, d6-DMSO) δ 12.63 (s, 1H), 6.88 (s, 1H), 6.66 (d, J=12.4 Hz, 1H), 6.61 (d, J=8.8 Hz, 1H), 6.40 (d, J=9.2 Hz, 1H), 3.71 (d, J=9.6 Hz, 1H), 0.98 (s, 9H).

Provenance & Evidence