Hydrochloric Acid → HCID 67103382, compound

Participants

Reaction Steps

(3R,5S)-1-(tert-butoxycarbonyl)-5-((1R,2R)-1-(cyclopropylsulfonylcarbamoyl)-2-ethylcyclopropylcarbamoyl)pyrrolidin-3-yl 4-chloroisoindoline-2-carboxylate (1.35 g, 2.16 mmol) in DCM (5 mL) was added 4 N HCl in dioxane (4.32 ml, 17.3 mmol). The reaction mixture was stirred at rt for 2 hours. The solvent was removed and the residue was suspended in ethyl ether (30 mL) and stirred for 30 min. The solid was collected by filtration to give (3R,5S)-5-((1R,2R)-1-(cyclopropylsulfonylcarbamoyl)-2-ethylcyclopropylcarbamoyl)pyrrolidin-3-yl 4-chloroisoindoline-2-carboxylate dihydrochloride (1.10 g, 91%) as white solid. LCMS (APCI+): 525.2.

Provenance & Evidence