HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethyl 2-hydroxyisobutyrate → Ethyl 2-(2-chloro-5-nitro-benzoyloxy)-2-methyl-propionate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethyl 2-hydroxyisobutyrate | HCID 6653 | — |
| Reactant | 2-Chloro-5-nitrobenzoic acid | HCID 17287 | — |
| Product | Ethyl 2-(2-chloro-5-nitro-benzoyloxy)-2-methyl-propionate | HCID 19780825 | — |
Reaction Steps
Analogously to the procedure described in Example 74, from 2-chloro-5-nitro-benzoic acid via its acid chloride and ethyl α-hydroxy-isobutyrate there is obtained ethyl 2-(2-chloro-5-nitro-benzoyloxy)-2-methyl-propionate, m.p. 64°-66° C., which is subsequently reduced to ethyl 2-(5-amino-2-chloro-benzoyloxy)-2-methyl-propionate. B.p. 200°-230° C./0.1 torr;
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05183492 |
| Source dataset | uspto-grants-1993_02 |
| ORD ID | ord-afd8b0d01e3740448d9ac0229a4d03bc |
| Source note | uspto-grants-1993_02 |